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Conagen Successfully Develops Antioxidant Kaempferol by Precision Fermentation

Bedford, Mass., Jan. 05, 2022 (GLOBE NEWSWIRE) — Conagen, the Massachusetts-based biotechnology innovator, announced the successful development of antioxidant kaempferol produced by state-of-the-art, proprietary, precision fermentation. As a biotechnology company specializing in developing commercially valuable molecules for its partners and clients, Conagen’s kaempferol enables brands in nutrition, beauty, and personal care products to adopt a more natural position by formulating with clean and sustainable kaempferol.Recognized as one of nature’s most potent antioxidants, kaempferol is a flavonoid with health-promoting properties found in tea, fruits, and vegetables, especially rich in green leafy vegetables such as spinach and kale.

Rising consumer awareness towards chronic diseases such as cancer and diabetes drives the kaempferol market demand. The global kaempferol market may exceed $6.5 billion by 2025, according to a recent research report by Global Market Insights, Inc.

“We’re bringing to market a pure and natural kaempferol at affordable prices that were not possible or available until now,” said Casey Lippmeier, Ph.D. vice president of innovation at Conagen. “Conagen’s scalable, precision fermentation for producing flavonoids like kaempferol is more efficient and sustainable than what can be achieved with the chemically-synthesized or botanically-sourced molecule.”

Flavonoids are polyphenolic compounds commonly found in plants and are a significant part of the human diet. They are biosynthesized by plants and fungi as secondary metabolites and comprise a diverse group of phytonutrients.

Plants protect themselves and their fruits against biological intruders such as fungi and bacteria by using phenolic phytochemicals, including flavonoids. Accordingly, kaempferol provides powerful anti-microbial, anti-inflammatory, and immune system benefits to humans.

Dietary kaempferol in multiple studies has demonstrated a wide range of promising beneficial activities, primarily as an anti-inflammatory and antioxidant, for reducing the risk of chronic diseases, especially cancer.

Prolonged oxidative stress leads to premature aging and can trigger many degenerative diseases and cancer. Kaempferol’s powerful antioxidant property can help the body’s defense against free radicals that promote cancer development.

Conagen derived kaempferol from its molecular platform for flavonoid antioxidants, including the previously announced molecules: DHQ, also known as Taxifolin, p-coumaric acid, hydroxytyrosol, and rosmarinic acid. The development of natural kaempferol is good news for Conagen’s commercialization partner, Blue California, as kaempferol will expand its offerings of specialty ingredient solutions.

“This launch further demonstrates our talent for delivering innovative compounds which are ideal for dietary supplements and ‘clean-label’ ingredients for functional foods, beverages, and cosmetics,” said Lippmeier. “Our vision for promoting health and wellness is to continuously leverage our precision fermentation capabilities for high-quality phenolic and flavonoid phytonutrients, thus confirming our position as a leader in the development of strains and processes for making clean-label ingredients and nutraceuticals.”

Blue California has a long-standing partnership with biotechnology innovator Conagen. Conagen focuses on developing sustainable, nature-based ingredients that improve existing options in the market or represent completely novel ingredient solutions.

About Conagen

Conagen is a product-focused, synthetic biology R&D company with large-scale contract manufacturing capabilities. Our scientists and engineers use the latest synthetic biology tools to develop high-quality, sustainable, nature-based products by precision fermentation and enzymatic bioconversion. We focus on the bioproduction of high-value ingredients for food, nutrition, flavors and fragrances, pharmaceutical, and renewable materials industries.

About Blue California

Blue California is a vertically integrated technology company providing innovative ingredient solutions to global partners. With more than 20 years of innovation success, our ingredients are used in commercial products and applications in nutrition, personal care, healthy aging and wellness, functional food and beverage, and beauty.


Ana Arakelian, Head of Public Relations and Communications

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